Project H.M. Phase 2 Overview

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Once the collection of tissue slices from the brain of patient H.M. was safely archived cryo-genically, the work towards reconstructing a neurological picture of the case began.

The main goals of Phase 2 of the project that are expected to be completed by the end of 2011 are:

1. The exact cytological localization of the surgical lesion.

2. The application of histological staining using multiple markers to assess the pathological state of the brain.

3. The complete multimodal characterization of the case using multiple neuroimaging datasets, including: MRI, DTI, and blockface imaging in relation to images of microscopic anatomy acquired from selected giant histological sections. Whole giant tissue sections will be digitized at 20X and will be viewable within a dedicated web site. The web site will also enable shared consultation and annotation.