Welcome to Project H.M.

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We believe that the enormous attention that was devoted to patient H.M. when he was living and generously served as a keen research subject ought to be matched by a similarly involved study of his brain.

To that effect, we will strive to conduct the most detailed and complete neuropathological analysis possible. The brain specimen will be processed and examined whole as multiple series of stained giant histological slides. The study is also designed to leverage on several complementary neuroimaging modalities, including MRI and blockface imaging, that will ultimately illustrate and measure the brain of patient H.M. both at the system and at the cellular level.

In order to maximize the impact of H.M.’s final donation to science, we would like to invite our colleagues to join this forum of discussion. This blog is primarily intended as a technical forum, at least initially, and it is meant to provide the space for a collaborative evaluation of the methods and scientific priorities most pertinent to this case.